History and Introduction
Platelet Rich Plasma (PRP) sometimes referred to as Autologous (using patient’s own blood) is exactly that, a gel harvested from someone’s blood whereby a high number of platelets are concentrated. Blood is made up of red blood cells, white blood cells, plasma and platelets. Platelets are known to aid in the healing process of all wounds and therefore the regeneration of cells. New data show that platelets release large doses of bioactive proteins, known as growth factors responsible for attracting macrophages, mesenchymal stem cells and osteoblasts which promote the removal of necrotic tissue and enhance tissue regeneration and repair.
PRP was first widely used in the dental community to aid in the healing process of implants, jaw reconstruction and even gum tissue regeneration. Some physicians have found it useful in several medical specialties: sports medicine, ophthalmology, dermatology, neurosurgery, orthopedics, ENT (Ear, Nose and Throat) and cosmetic surgery.
Collagen repair is normally separated into 3 distinct phases; inflammation, proliferation and remodeling. During the inflammation stage which is approximately 3 days the growth factors are released. During the proliferation stage fibroblasts attack the area requiring healing; this can last several weeks during which time neovascularization (development of new blood vessels) occurs. The final stage of the growth or healing process is known as remodeling during which the newly created collagen strengthens. This stage is ongoing and can last over a year.
If physicians use a product for an indication not in the approved labeling, they have to inform the patient, adhere to good medical practice and have the responsibility to be well informed about the product, to base its use on firm scientific rationale and on sound medical evidence and to maintain records of the product’s use and effects (source: www.fda.gov)